Publications

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Systematic Comparison of Commercial Uranyl-Alternative Stains for Negative- and Positive-Staining Transmission Electron Microscopy of Organic Specimens

Vera M Kissling , Stephanie Eitner, Davide Bottone, Gea Cereghetti, Peter Wick

 Advanced Healthcare Materials, 2025

Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors

Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer

Cell Communication and Signaling, 2025

Oxidation-sensitive cysteines drive IL-38 amyloid formation

Alejandro Diaz-Barreiro*, Gea Cereghetti*, Francisco Gabriel Ortega Sánchez, Jenna Tonacini, Dominique Talabot-Ayer, Sylvie Kieffer-Jaquinod, Vera Maria Kissling, Arnaud Huard, Christopher Swale, Tuomas P J Knowles, Yohann Couté, Matthias Peter, Antonio Francés-Monerris, Gaby Palmer

Cell Reports, 2024

An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions

Gea Cereghetti, Vera M Kissling*, Lisa M Koch*, Alexandra Arm*, Claudia C Schmidt, Yannik Thüringer, Nicola Zamboni, Pavel Afanasyev, Miriam Linsenmeier, Cédric Eichmann, Sonja Kroschwald, Jiangtao Zhou, Yiping Cao, Dorota M Pfizenmaier, Thomas Wiegand, Riccardo Cadalbert, Govind Gupta, Daniel Boehringer, Tuomas P J Knowles, Raffaele Mezzenga, Paolo Arosio, Roland Riek, Matthias Peter

Developmental Cell, 2024

A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein

Lukas Frey*, Jiangtao Zhou*, Gea Cereghetti, Marco E Weber, David Rhyner, Aditya Pokharna, Luca Wenchel, Harindranath Kadavath, Yiping Cao, Beat H Meier, Matthias Peter, Jason Greenwald, Roland Riek, Raffaele Mezzenga

Nature Communications, 2024

Mre11-Rad50 oligomerization promotes DNA double-strand break repair

Vera M Kissling, Giordano Reginato*, Eliana Bianco*, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphaël Guérois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter

Nature Communications, 2022

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Gea Cereghetti, Caroline Wilson-Zbinden*, Vera M Kissling*, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, Paola Picotti, D Allan Drummond, Uwe Sauer, Reinhard Dechant, Matthias Peter

Nature Cell Biology, 2021

Highlighted in:
• Nature Cell Biology News & Views – Metabolites control stress granule disassembly

• ETH Zürich News – Reversible amyloids of pyruvate kinase couple metabolism and stress granule disassembly

High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes

Gregor Holzner, Bogdan Mateescu, Daniel van Leeuwen, Gea Cereghetti, Reinhard Dechant, Stavros Stavrakis, Andrew deMello

Cell Reports, 2021

Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins

Andre Melnik, Valentina Cappelletti, Federico Vaggi, Ilaria Piazza, Marco Tognetti, Carmen Schwarz, Gea Cereghetti, Mennat Allah Ahmed, Martin Soste, Kent Matlack, Natalie de Souza, Attila Csikasz-Nagy, Paola Picotti

Journal of Proteomics, 2020

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease

Ana Griciuc, Shaun Patel, Anthony N Federico, Se Hoon Choi, Brendan J Innes, Mary K Oram, Gea Cereghetti, Danielle McGinty, Anthony Anselmo, Ruslan I Sadreyev, Suzanne E Hickman, Joseph El Khoury, Marco Colonna, Rudolph E Tanzi

Neuron, 2019

Highlighted in:

Reversible, functional amyloids: towards an understanding of their regulation in yeast and humans​

Gea Cereghetti , Shady Saad, Reinhard Dechant, Matthias Peter

Cell Cycle, 2018

A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro

Erica Grignaschi, Gea Cereghetti, Fulvio Grigolato, Marie R G Kopp, Stefano Caimi, Lenka Faltova, Shady Saad, Matthias Peter, Paolo Arosio

Journal of Biological Chemistry, 2018

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

Shady Saad, Gea Cereghetti, Yuehan Feng, Paola Picotti, Matthias Peter, Reinhard Dechant

Nature Cell Biology, 2017

Highlighted in:

• ETH Zürich News – Clumps as temporary storage
• Nature Cell Biology News & Views – Preserving protein function through reversible aggregation
• Developmental Cell – Lessons from Yeast on How to Avoid Stress Eating